1 . Chemical approaches to sphingolipid research
نویسندگان
چکیده
Sphingolipids are an important group of biomolecules that play important roles in the regulation of many cell functions. Many efforts have been made in recent years to design analogs suitable for a better understanding of the biological and biophysical roles of sphingolipids. In this review, some of the most relevant contributions in the field from our group are collected. In particular, this review deals with the development of new sphingolipid analogs as acid ceramidase inhibitors, and the design of fluorogenic probes to screen enzyme activities and to the study of biophysical properties.
منابع مشابه
Total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1).
The first total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1) has been achieved. This convergent synthesis utilizes oxonia Cope rearrangements to prepare two key homoallylic alcohols, which are then functionalized to the primary components A and B for cross-coupling. Other highlights of our approach include a new and efficient synthesis of the diprotected tricarballylic ac...
متن کاملElucidating the chemical structure of native 1-deoxysphingosine.
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and diabetes type 2 and might contribute to β cell failure and the diabetic sensory neuropathy. In anal...
متن کاملA new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata.
From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2',3'-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(-) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were cha...
متن کاملA method for visualization of “omic” datasets for sphingolipid metabolism to predict potentially interesting differences[S]
Sphingolipids are structurally diverse and their metabolic pathways highly complex, which makes it difficult to follow all of the subspecies in a biological system, even using "lipidomic" approaches. This report describes a method to use transcriptomic data to visualize and predict potential differences in sphingolipid composition, and it illustrates its use with published data for cancer cell ...
متن کاملLabeled chemical biology tools for investigating sphingolipid metabolism, trafficking and interaction with lipids and proteins.
The unraveling of sphingolipid metabolism and function in the last 40 years relied on the extensive study of inherited human disease and specifically-tailored mouse models. However, only few of the achievements made so far would have been possible without chemical biology tools, such as fluorescent and/or radio-labeled and other artificial substrates, (mechanism-based) enzyme inhibitors, cross-...
متن کامل